Caspase-9 Antibody

Synonimy: Apoptotic protease Mch-6, Apoptotic protease-activating factor 3, ICE-like apoptotic protease 6
Typ przeciwciała: Polyclonal
Pochodzenie: Rabbit
Izotyp: Rabbit IgG
Klon:
Reaktywność: Human
Immunogen: Recombinant protein of human Caspase-9 (Cat # 1089)
NCBI: P55211
Gene ID: 842
Stężenie: 0.5 mg/ml
100 µg (0.5 mg/ml) of antibody in PBS pH 7.2 containing 0.01 % BSA, 0.01 % thimerosal, and 50 % glycerol.
Przeznaczenie: Western blot
Western blot: 1-4 µg/ml.
For Research Use Only! Not to be used in humans.
Informacje: Caspases are synthesized as inactive pro-enzymes that are processed to active form in cells undergoing apoptosis. Caspase-9 is an important member of the caspase family. Upon induction of apoptosis, Cytochrome c released from mitochondria associates with pro-caspase-9 (47 kDa) and Apaf-1. The complex processes pro-caspase-9 into a large subunit (37 kDa/17 kDa) and a small subunit (10 kDa). Cleaved caspase-9 further processes other caspases including caspase-3 and caspase-6, to initiate a caspase cascade leading to apoptosis. The affinity purified antibody recognizing the active forms of caspase-9 provides a new tool for identifying apoptotic cell populations in both tissue sections and cultured cells.
Temp. przechowywania: -20 °C
Czas przydatności: 12 months