NNMT Antibody

Synonimy: Nicotinamide N-methyltransferase
Typ przeciwciała: Polyclonal
Pochodzenie: Rabbit
Izotyp: Rabbit IgG
Klon:
Reaktywność: Human
Immunogen: Recombinant protein of human Nicotinamide N-Methyltransferase
NCBI: P40261
Gene ID: 4837
Stężenie: 0.5 mg/ml
100 µg (0.5 mg/ml) of antibody in PBS pH 7.2 containing 0.01 % BSA, 0.01 % thimerosal, and 50 % glycerol.
Przeznaczenie: Western blot
Western blot: 1-4 µg/ml.
For Research Use Only! Not to be used in humans.
Informacje: N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. NNMT is an important cytosolic methyltransferase catalyzing the N-methylation of nicotinamide, pyridines and structural analogs, playing a crucial role in the biotransformation and detoxification of many xenobiotic compounds. In the N-methylation process, NNMT uses S-adenosyl methionine as the methyl donor and nicotinamide as methyl acceptor. NNMT is mostly expressed in the liver, and a lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. It may also play an important role in regulating biological processes related to N-methyl nicotinamide such as anti-inflammatory, anti-thrombotic, vasoprotective, and gastroprotective properties. Increased NNMT activity was reported in many kinds of tumors. NNMT is a potential biomarker and therapeutic target in cancer diagnosis and treatment. NNMT serum levels have significance in the premature detection and in the management of patients with colorectal cancer.
Temp. przechowywania: -20 °C
Czas przydatności: 12 months