NKp30(NCR3) antibody (clone y4E6)

Natural cytotoxicity triggering receptor 3(termed Nkp30or NCR3) is a member of the Ig superfamily that may cooperate with Nkp46 and Nkp44 in the induction of cytotoxicity against a variety of target cells and is selectively expressed by all Nk cells, both freshly isolated and cultured in IL-2, thus representing an optimal marker for Nk cell identification. Similar to Nkp46 and CD16, Nkp30 associated with CD3zeta chains that become tyrosine phosphorylated following cell treatment with pervanadate. Its extracelluar portion is characterized by a single domain of the V-type and by a region rich in hydrophobic amino acids, potentially involved in protein/protein interactions that connects the Ig V-like domain with the transmembrane portion.