CXCR4 Antibody

Synonimy: chemokine C-X-C motif receptor 4, chemokine receptor 4
Typ przeciwciała: Polyclonal
Pochodzenie: Rabbit
Izotyp: Rabbit IgG
Klon:
Reaktywność: Mouse, rat
Immunogen: E. coli-expressed rat CXCR4
NCBI: O08565
Gene ID: NM_022205. rat.
Stężenie: 0.5 mg/ml
100 µg (0.5 mg/ml) protein A purified rabbit anti-CXCR4 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.01% thimerosal.
Przeznaczenie: Western blot/, Neutralization, Flow cytometry
Western blot analysis (1 µg/ml), neutrolization and FACS analysis. However, the optimal conditions should be determined individually.
For Research Use Only! Not to be used in humans.
Informacje: CXCR4 (fusin) is a member in the seven-transmembrane domain G-protein-coupled chemokine receptor family. The full-length cDNA was isolated from a human spleen cDNA library. Its ligand is chemokine stroma-derived factor (SDF). CXCR4 has been shown to be the co-receptor for HIV-1 binding to CD4 throμgh the viral envelope glycoprotein gp120. In other cases, CXCR4 can function as the only receptor for the interaction of HIV-2 with CD4 and host cells. A mouse monoclonal antibody (12G5) to CXCR4 has been shown to inhibit HIV infectivity and HIV-induced syncytium.
Temp. przechowywania: -20 °C
Czas przydatności: 12 months