LRP-5/6 Antibody (Clone 1A12)

Synonimy: LRP-5, LRP-6, LDL-related protein, LDL receptor, Axin, beta-catenin
Typ przeciwciała: Monoclonal
Pochodzenie: Mouse
Izotyp: Mouse IgG2bk
Klon: 1A12
Reaktywność: Human, mouse
Immunogen: Synthetic peptide derived from human LRP-6
NCBI: O75197
Gene ID: 4041
Stężenie: 1.0 mg/ml
100 µg (1 mg/ml) purified antibody in 10 mM Tris-glycine (pH 7.0), 0.15 M NaCl, 25% glycerol, 0.5% BSA, and 0.01% sodium azide.
Przeznaczenie: Western blot
Western blot analysis (1-2 µg/ml). However, the optimal conditions should be determined individually. Detects full length and a proteolytic fragment of LRP-6.
For Research Use Only! Not to be used in humans.
Informacje: LDL-related proteins, LRP-5 and LRP-6, are members of the LDL receptor superfamily, which were found to be involved in the canonical Wnt signaling pathway. Mammalian LRP-6 was shown to bind to Wnt-1 and enhance Wnt-induced developmental processes in Xenopus embryos. Mice lacking LRP-6 exhibited developmental defects that are similar to those caused by deficiencies in various Wnt proteins. Recent work also shows that Wnt proteins induce the binding of LRP-5 to Axin, leading Axin degradation and β-catenin stabilization.
Temp. przechowywania: -20 °C
Czas przydatności: 12 months